Bloocell® Clinical Studies
Mineralization of PCL/TCP
Goldner’s trichrome staining (mineralized tissue = green; osteoid = red) reveals newly formed woven bone trabeculae after 4 weeks along with the presence of numerous blood vessels distributed across the defect site (A) (10X magnification). Multi-nucleated giant cells are detected on the surfaces of the scaffold rods and are closely associated with adipose cells as early as 4 weeks after implantation (B) (40X magnification).
Yeo et al. Surface Modification Of PCL-TCP Scaffolds In Rabbit Calvaria Defects: Evaluation Of Scaffold Degradation Profile, Biomechanical Properties And Bone Healing Patterns, Journal Of Biomedical Materials Research
Anti-inflammatory effect of HA
Summary of the pro-inflammatory and anti-inflammatory responses of hyaluronic acid. CD44 = cluster determinant 44; eCM = extracellular matrix; erKs = extracellular signal-regulated kinases; FaK = focal adhesion kinase; Ha = hyaluronic acid; Her2 = human epidermal growth factor receptor 2; HYal = hyaluronidase; iCaM = intercellular adhesion molecule–1; iCM = intracellular matrix; il = interleukin; iraK = interleukin-1 receptor-associated kinase; MaPK = mitogen activated protein (MaP) kinase; MMP = matrix metalloproteinase; MyD88 = myeloid differentiation primary response 88, NF-κB = nuclear factor kappa-light-chain-enhancer of activated B cells; NO = nitric oxide; Pg = proteoglycan; Pge = prostaglandin e2; taK1 = transforming growth factor-β (tgF-β)-activated kinase; tal1 = t-cell acute lymphocytic leukemia protein 1; tiMP = tissue inhibitor of metalloproteinases; tlr = toll like receptor; tNF = tumor necrosis factor; traF6 = tNF receptor associated factors.
In Safranin O staining of chondrogenesis, positive staining of proteoglycan (red) is markedly noted around outer margins of the grafted PCL mesh; space of grafted PCL implant (P) was well maintained. In a high-magnification field, the chondrocyte and lacunae (black arrow) characterized by specific structure for the chondrocyte were noted. P: cavity of grafted PCL mesh (original magnification: 40X;(a), 400X (b))
Park et al. Clinical Application of Three-Dimensionally Printed Biomaterial Polycaprolactone (PCL) in Augmentation Rhinoplasty, Aesthetic Plastic Surgery
Assessment of cell viability and vascularization"
H&E and MT staining images are shown. No inflammation or any immune response was observed. a, b Histological image of H&E staining; c, d histological image of MT staining. P: cavity of grafted PCL mesh, black arrow: fibrovascular tissue (original magnification: 40X (surrounding host tissue in a critical-sized rabbit, c), 100X (b, d))
Morphology analysis
Gross appearance and microscopic morphology of the poly- caprolactone (PCL) mesh confirmed by field emission scanning electron microscope. Sheet-type PCL scaffold mesh with a uniform line. b and c fully interconnected triangular pores in PCL mesh
Park et al. Clinical Application of Three-Dimensionally Printed Biomaterial Polycaprolactone (PCL) in Augmentation Rhinoplasty, Aesthetic Plastic Surgery
Immunohistochemistry staining of collagen type I is shown in brown. Each collagen is indicated with black arrow lines. P: cavity of grafted PCL mesh (original magnification: 40X (a), 100 X (b))
The collagen-stimulating effect of PCL
Immunohistochemistry staining of collagen type I is shown in brown. Each collagen is indicated with black arrow lines. P: cavity of grafted PCL mesh (original magnification: 40X (a), 100 X (b))
Clinical Application of Three-Dimensionally Printed Biomaterial Polycaprolatone (PCL) in Augmentation Rhinoplasty
Use of 3D printed polycaprolactone + hyaluronic acid-based scaffold in orthopedics practice: A report of two cases
Use of 3D printed polycaprolactone + hyaluronic acid-based scaffold in orthopedics practice: A report of two cases Erdi Ozdemir, Filippo Familiari, Ahmet Fırat, Gazi Huri. Journal of 3D Printing in Medicine, DOI: 10.2217/3dp-2022-0020
Case 1: 42-year-old patient showing Hamada 4B left glenohumeral osteoarthritis.
Case 2: 19-year-old patient with neglected Galeazzi fracture–dislocation and radius non-union.
THE SUCCESS OF BLOOCELL® TECHNOLOGY CONTINUES TO BE PUBLISHED IN LEADING SCIENTIFIC CONGRESSES
