Guide to Bloocell® Growth Factors
Bloocell Ortho products are suitable for tumour, non-union, mosaicplasty, acetabulum defects, glenohumeral osteoarthritis etc. for all surgeries requiring graft technique.
Bloocell Bioscaffold is superior to other biomaterials with its "structural adaptation" and "natural mechanical compensation" properties. The Bloocell Brand has been created by taking the answer of all our studies that have started for many years and continue today.
Mineralization of PCL/TCP
Goldner’s trichrome staining (mineralized tissue = green; osteoid = red) reveals newly formed woven bone trabeculae after 4 weeks along with the presence of numerous blood vessels distributed across the defect site (A) (103 magnification). Multi-nucleated giant cells are detected on the surfaces of the scaffold rods and are closely associated with adipose cells as early as 4 weeks after implantation (B) (403 magnification).
Yeo et al. Surface Modification Of PCL-TCP Scaffolds In Rabbit Calvaria Defects: Evaluation Of Scaffold Degradation Profile, Biomechanical Properties And Bone Healing Patterns, Journal Of Biomedical Materials Research
Anti-inflammatory effect of HA
Summary of the pro-inflammatory and anti-inflammatory responses of hyaluronic acid. CD44 = cluster determinant 44; eCM = extracellular matrix; erKs = extracellular signal-regulated kinases; FaK = focal adhesion kinase; Ha = hyaluronic acid; Her2 = human epidermal growth factor receptor 2; HYal = hyaluronidase; iCaM = intercellular adhesion molecule–1; iCM = intracellular matrix; il = interleukin; iraK = interleukin-1 receptor-associated kinase; MaPK = mitogen activated protein (MaP) kinase; MMP = matrix metalloproteinase; MyD88 = myeloid differentiation primary response 88, NF-κB = nuclear factor kappa-light-chain-enhancer of activated B cells; NO = nitric oxide; Pg = proteoglycan; Pge = prostaglandin e2; taK1 = transforming growth factor-β (tgF-β)-activated kinase; tal1 = t-cell acute lymphocytic leukemia protein 1; tiMP = tissue inhibitor of metalloproteinases; tlr = toll like receptor; tNF = tumor necrosis factor; traF6 = tNF receptor associated factors.
Gross appearance and microscopic morphology of the poly- caprolactone (PCL) mesh confirmed by field emission scanning electron microscope (S-4700; HITACHI Co., Tokyo, Japan). a Sheet-type PCL scaffold mesh with a uniform line. b and c Fully interconnected triangular pores in PCL mesh
In Safranin O staining of chondrogenesis, positive staining of proteoglycan (red) is markedly noted around outer margins of the grafted PCL mesh; space of grafted PCL implant (P) was well maintained. In a high-magnification field, the chondrocyte and lacunae (black arrow) characterized by specific structure for the chondrocyte were noted. P: cavity of grafted PCL mesh (original magnification: 40 9 (a), 400 9 (b))
Park et al. Clinical Application of Three-Dimensionally Printed Biomaterial Polycaprolactone (PCL) in Augmentation Rhinoplasty, Aesthetic Plastic Surgery
Assessment of cell viability and vascularization"
H&E and MT staining images are shown. No inflammation or any immune response was observed. a, b Histological image of H&E staining; c, d histological image of MT staining. P: cavity of grafted PCL mesh, black arrow: fibrovascular tissue (original magnification: 40 9 (surrounding host tissue in a critical-sized rabbit, c), 100 9 (b, d))
H&E and MT staining images are shown. No inflammation or any immune response was observed. a, b Histological image of H&E staining; c, d histological image of MT staining. P: cavity of grafted PCL mesh, black arrow: fibrovascular tissue (original magnification: 40 9 (surrounding host tissue in a critical-sized rabbit, c), 100 9 (b, d))
Morphology analysi
Gross appearance and microscopic morphology of the poly- caprolactone (PCL) mesh confirmed by field emission scanning electron microscope (S-4700; HITACHI Co., Tokyo, Japan). a Sheet-type PCL scaffold mesh with a uniform line. b and c Fully interconnected triangular pores in PCL mesh
Park et al. Clinical Application of Three-Dimensionally Printed Biomaterial Polycaprolactone (PCL) in Augmentation Rhinoplasty, Aesthetic Plastic Surgery
Immunohistochemistry staining of collagen type I is shown in brown. Each collagen is indicated with black arrow lines. P: cavity of grafted PCL mesh (original magnification: 40 9 (a), 100 9 (b))
The collagen-stimulating effect of PCL
Immunohistochemistry staining of collagen type I is shown in brown. Each collagen is indicated with black arrow lines. P: cavity of grafted PCL mesh (original magnification: 40 9 (a), 100 9 (b))
Clinical Application of Three-Dimensionally Printed Biomaterial Polycaprolatone (PCL) in Augmentation Rhinoplasty